Wednesday, May 8, 3:30-4:30pm, WEL 2.122
Jay and Ann Schenck Professor
University of Illinois
The Lu Group’s interests lie at the interface between chemistry and biology. We are developing innovative chemical approaches to provide deeper insight into biological structures and functions, while also taking advantage of recently developed biological tools to advance many areas in chemistry, such as inorganic chemistry, chemical biology, analytical chemistry, and materials chemistry. Novel Sensing and Imaging Agents for Metals and Other Metabolites in Environmental Monitoring, Food Safety, Medical Diagnostic and Therapy: Selective sensors and imaging agents are very useful for on-site and real-time detection in environmental monitoring, food safety, medical diagnostics, and imaging. While much progress has been made in detecting large molecule targets, such as nucleic acids and proteins, sensing and imaging small molecule targets and biomarkers, such as metal ions and organic metabolites, remain difficult because they are very large in different species, subtle in structural differences, and present in trace amounts. Therefore, detection in metabolomics has become a new frontier for chemical biologists following advancements made in genomics and proteomics. We have identified challenges in both fundamental science and in technological development, and we have made significant progress in meeting these challenges.
h-index: 88 Total Citations: 32,237 (Google Scholar Citations, Apr. 2019)
Wednesday, February 13, 3:30-4:30pm, WEL 2.122
Global challenges in the areas of chemical catalysis, energy storage and utilization, and environmental stewardship require new methods for controlling the selectivity and efficiency of inner-sphere reactions at solid-liquid interfaces. Our group works to solve these problems via bottom-up, molecular-level engineering of functional inorganic interfaces with a focus on electrochemical energy conversion.
h-index: 33 Total Articles: 53 Total Citations: 6826 (Web of Science, Jan. 2019)
Wednesday, February 6, 3:30-4:30pm, WEL 2.122
University of Colorado Boulder
Our research lies at the interface of chemistry and biology, where the application of chemical and physical principles provides a unique opportunity to better understand the fundamental biochemistry of living cells. Cells are complex entities that must integrate internal and external signals in order to coordinate diverse functions. Living cells are also dynamic, and this dynamism is key to understanding the mechanisms between cause and effect for biological processes. Deciphering the molecular details of how cellular constituents define healthy and diseased states, and how dynamics propagate from the cellular to the organismal level, is one of the great challenges in modern biology. Our lab develops new technologies to interrogate signaling cascades in cells to understand how the actions of specific proteins, molecules, and ions contribute to cellular function. We combine in vitro spectroscopic and biophysical techniques with protein design and engineering to develop novel fluorescent probes, and use long-term time-lapse fluorescence microscopy to elucidate the mechanisms of cellular signaling pathways. Longitudinal single-cell analyses also allow us to explore the origins and consequences of heterogeneity in biological systems. We are specifically interested in how cells regulate metal ions, how pathogens alter cell biology, and how to engineer improved photophysical properties in fluorescent proteins.
h-index: 36 Total Articles: 67 Total Citations: 10,007 (Web of Science, Jan. 2019)
Faculty Recruiting Seminar
Thursday, January 24, 3:30-4:30pm, WEL 2.122
University of Washington
PhD Caltech, 2016 (Jonas Peters)
The Gamelin group's research targets the development and physical characterization of new functional inorganic materials with unusual electronic structures that give rise to desirable photophysical, photochemical, chemical, electronic, magnetic, or magneto-optical properties.
h-index: 10 Total Citations: 629 (Google Scholar Citations, Jan. 2019)
h-index: 10 Total Articles: 13 Total Citations: 509 (Web of Science, Jan. 2019)
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