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Chemistry Guest Seminars

Organic Seminars 2019

Department Seminar

Friday, March 29, 3:30-4:30pm, Avaya Auditorium, POB 2.302boyer

Photoinduced Electron/Energy Transfer – Reversible Addition Fragmentation Chain Transfer Polymerisation (PET-RAFT): An efficient Tool for Polymer Synthesis

Cyrille Boyer

Professor, Chemical Engineering

University of New South Wales

Boyer Lab

Our research is centred on the development of environmentally friendly techniques for the synthesis of functional polymeric materials.  A major focus is photoinduced electron/energy transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerisation where we are continuing to develop novel photoredox catalysts.

We are also developing various polymerisation techniques for visible-light-cotrolled radical polymerisation, such as continous flow PET-RAFT polymerisation and high-throughput synthesis of polymers through photopolymerisation in open-air.  Furthermore, we are exploring photopolymerisation in dispersed media for the synthesis of polymeric nanoparticles through polymerisiation-induced self assembly (photo-PISA).  Another focus is adapting the aforementioned techniques to the fabrication of advanced polymeric materials for  new synthetic antimicrobial macromolecules.

2018 Polymer Chemistry Lectureship awarded to Cyrille Boyer


Publications (Group Site)
Publications (Google Scholar Citations)

Author Metrics

h-index: 61  Total Articles: 206 Total Citations:  10,695  (Web of Science, Mar. 2019)

h-index: 69  Total Citations:  13,998  (Google Scholar Citations, Mar. 2019)

Monday, March 25, 3:30-4:30pm, WEL 2.122nagib

C-H and C-O Functionalization via Radical Chaperones

David Nagib

Assistant Professor

Ohio State University

Group Web Site

The Nagib Laboratory seeks to bridge the gap between what is possible and practical in the realm of organic synthesis. Our goal is to expand the synthetic toolbox by designing fundamentally new activation strategies and catalysts. We aim to harness the untapped reactivity of cheap and abundant chemical feedstocks as well as enable the late-stage functionalization of complex natural products. We are currently inventing multi-faceted approaches for selective C-H and C-O activation, using combinations of radical (1e-) and closed shell (2e-) processes. By emphasizing the design of novel, dual-catalytic strategies (organometallic, organocatalytic, redox-neutral, etc.) and a careful elucidation of their unique mechanisms, we are developing useful methodologies to enable non-classical synthetic disconnections. Our chemistry has important applications in various interdisciplinary arenas, including the streamlined synthesis of improved medicines, materials, and biofuels.


Publications (Group Site)

Publications (Google Scholar)

ORCID: https://orcid.org/0000-0002-2275-6381

Author Metrics

h-index: 7  Total Articles: 12 Total Citations:  1795  (Web of Science, Mar. 2019)

h-index: 7 Total Citations: 2096 (Google Scholar Citations, Mar. 2019)

Friday, March 1, 3:30-4:30pm, WEL 2.122newhouse

Synthesis of Neuroactive Terpenoids Using Chemical and Computational Strategies

Timothy Newhouse

Associate Professor

Yale University

Group Web Site

Despite the power of modern organic chemistry, efficient synthesis of complex molecular scaffolds remains an unmet challenge.  Their intricate ring systems and stereochemical arrays require too many synthetic operations to rapidly produce libraries of analogs.  New technological approaches are needed to forge their varied bonds to provide scalable access to libraries of these molecular architectures.  Through detailed mechanistic study, such technologies can be developed.

The development of general construction reactions will have broad utility in a range of fields that rely on the synthesis of small molecules and functional materials.  One particular area that the Newhouse group focuses on is the total chemical synthesis of carbocyclic frameworks that are known to elicit powerful neurological effects.  These substances will both serve as chemical probes to study fundamental aspects of neurological function and address neurological dysfunction.

We focus our efforts on the development of new synthetic methods to rapidly acquire these structurally complex small molecules. These substances will be exploited for a variety of purposes by collaborating with neuroscientists.


Publications (Group Site)

Author Metrics

h-index: 11  Total Articles: 23 Total Citations:  307  (Web of Science, Feb. 2019)

Faculty Recruiting Seminar

Thursday, February 28, 1:00-2:00pm, WEL 2.122ackerman

Dual Metal Strategies for Catalytic C-C Bond Formation

Laura Ackerman

Postdoctoral Fellow

Princeton University

Abby Doyle Group

PhD, Rochester, 2016 (Daniel Weix)

Doyle Group research focus:  Research in our lab takes place at the interface between the fields of organic synthesis, organometallic catalysis, and physical organic chemistry. We are involved in designing synthetic strategies that enable efficient and selective preparation of complex molecules and biologically privileged structural motifs. To achieve these goals, we harness the activity of inexpensive and abundant transition metal catalysts to achieve novel bond-forming processes. Projects in the group are designed to provide students with expertise in reaction discovery and development, while exposing them to problems in complex target synthesis and mechanistic analysis.


Publications (Doyle Group)

Author Metrics

h-index:  6  Total Articles:  7  Total Citations: 323 (Web of Science, Jan. 2019)

Faculty Recruiting Seminar

Tuesday, February 26, 1:00-2:00pm, NHB 1.720biegasiewicz

Chemical and Enzymatic Strategies for Selective Synthesis

Kyle Biegasiewicz

Postdoctoral Fellow

Princeton University

Todd Hyster Group

PhD, Rochester, 2016 (Robert Boeckman)

Members of the Hyster group are trained in synthetic chemistry, organometallic chemistry and chemical biology with a strong emphasis on chemical reaction development.


Publications (Hyster Group)

Author Metrics

h-index:  5  Total Articles:  9  Total Citations: 79 (Web of Science, Feb. 2019)

Departmental Colloquium

Wednesday, February 20, 3:30-4:30pm, WEL 2.122Yaghi

Reticular Chemistry

Omar Yaghi

James and Neeltje Tretter Chair
Professor of Chemistry

University of California Berkeley

Group Web Site

In the Yaghi group we are building chemical structures by stitching molecules together into large and extended frameworks within which we can store hydrogen, methane, and separate carbon dioxide. The interior of the crystals is capable of compacting gases under ambient conditions thus foregoing the use of high pressures and low temperatures. In this movie, crystals of metal-organic framework-5 (MOF-5, numbered in roughly chronological order of discovery) are made and their structure is precisely designed to have zinc oxide units linked by organic struts (terephthalate) to make a porous network into which voluminous gases can be compacted and transported. This large open space is currently being used for positioning of organic and organometallic catalysts, charge storage for supercapacitors and binding of biological molecules such as proteins and metabolites.

Omar Yaghi awarded 2018 Wolf Prize
Pioneering chemist Omar Yaghi wins the Frontiers of Knowledge Award in Basic Sciences
Albert Einstein World Award of Science 2017


Publications (Group Site)

Publications (Google Scholar Citations)

ORCIDhttps://orcid.org/0000-0002-5611-3325

Author Metrics

h-index: 125   Total Articles: 253  Citations:  100,495 (Web of Science, Jan. 2019)

h-index: 140  Total Citations:  135,467 (Google Scholar Citations, Feb. 2019)

 

Friday, February 15, 3:30-4:30pm, WEL 2.122schanze

Water Soluble Conjugated Polymers: Properties and Applications in Sensing and Disinfection

Kirk Schanze

Professor and Robert A. Welch Distinguished University Chair in Chemistry

University of Texas San Antonio

Group Web Site

Research in the Schanze Labs is focused on the interaction of light with small molecules, polymers, and materials. We have an interest in photochemical and photophysical processes that are stimulated when molecular systems absorb light. Most of our current work centers on studies that explore the phenomenon of luminescence (light emission). In our fundamental work, we apply a variety of spectroscopic methods such as fluorescence spectroscopy and laser-induced time resolved fluorescence spectroscopy to gain information concerning the mechanisms of the light absorption and light emission processes. In applied work, we are using the light emission process of molecules and materials to develop novel light emitting devices (polymer LEDs), and novel fluorescent sensors. Some of our sensor systems are being used by aerodynamics engineers in wind-tunnel and mechanics tests and by chemists and biochemists for sensing analytes of interest.


Publications (Group Site)

ORCIDhttps://orcid.org/0000-0003-3342-4080

Author Metrics

h-index: 65  Total Articles: 270  Total Citations:  13,088  (Web of Science, Jan. 2019)

 

Monday, February 11, 3:30-4:30pm, WEL 2.122snaddon

Enantioselective Chemical Synthesis Methods via Cooperative Catalysis: Design, Development and Application

Thomas Snaddon

Assistant Professor

Indiana University

Group Web Site

Enantioselective cooperative catalysis: In the arena of reaction development, we leverage the power of catalysis to engineer new reactivity.  Through a synergistic union of Lewis base and transition metal catalysis, we have developed a platform for the enantioselective α‐functionalization of acyclic esters. This protocol effectively addresses long standing issues with control over enolate geometry of acyclic nucleophiles while simultaneously decoupling enantiocontrol – engendered by the Lewis base catalyst – and reactivity, which can be tailored by tuning the ligand sphere around the metal centre.  Targeted Synthesis:  We are also interested in applying our cooperative catalysis methodology in the area of targeted synthesis in order to identify efficient routes for the synthesis of a variety of natural product and drug-like molecules of biological interest.


Publications (Group Site)

ORCIDhttps://orcid.org/0000-0003-1119-0332

Author Metrics

h-index: 9  Total Articles: 16 Total Citations:  268 (Web of Science, Jan. 2019)

 

HHMI Lecture

Friday, February 8, 3:30-5:00pm, WEL 2.122johnson

Investigation of C-C Bond Activation: Mechanistic Understanding Leading to New Methodologies

Jeffrey B. Johnson

Associate Professor

Hope College

Group Web Site

Transition metal catalysis continually revolutionizes the synthesis of complex natural products and potential drug candidates by revealing reaction pathways inaccessible via traditional organic transformations. One area of current interest is the development of methodology for the cleavage and functionalization of carbon-carbon bonds. While carbon-carbon single bonds are inert under a vast majority of standard reaction conditions, certain transition metal complexes promote the activation of these bonds.


Publications (Profile Page)

ORCID:  https://orcid.org/0000-0003-1548-7117

Author Metrics

h-index: 12  Total Articles: 18  Total Citations:  757 (Web of Science, Jan. 2019)

 

Faculty Recruiting Seminar

Monday, February 4, 3:30-4:30pm, WEL 2.122tang

From Peptide Antibiotics to CRISPR-Mediated Synthetic Memories: Tools from the Microbial Arsenal

Weixin Tang

Postdoctoral Fellow

Harvard University

David R. Liu Group

PhD, Illinois, 2015 (W.A. van der Donk)

Liu Group research focus:  DNA-Templated Synthesis & DNA-Encoded Libraries:  Bioactive synthetic small molecules and synthetic polymers using DNA-templated organic synthesis, a technique pioneered by the Liu group, and Darwinian selection.  Protein evolution and delivery:  The laboratory evolution and in vivo delivery of proteins with therapeutic or biotechnological potential.  Genome editing:  The development and application of genome-editing proteins to study biology and to treat genetic diseases.


Publications (Google Scholar Citations)

Author Metrics

h-index:  12  Total Citations: 686 (Google Scholar Citations, Jan. 2019)

Monday, January 28, 3:30-4:30pm, WEL 2.122hargrove

Deciphering patterns in selective small molecule:RNA interactions

Amanda E. Hargrove

Assistant Professor

Duke University

Group Web Site

The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “Wild West.” Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids. Collaborations with the Department of Biology as well as colleagues in the School of Medicine ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.


Publications (Group Site)

ORCID:  https://orcid.org/0000-0003-1536-6753

Author Metrics

h-index: 12  Total Articles: 21  Total Citations:  703 (Web of Science, Jan. 2019)

 

Faculty Recruiting Seminar

Monday, January 14, 3:30-4:30pm, Avaya Auditorium, POB 2.302zhang

Novel Strategies in the Field of Synthetic Chemistry to Forge Carbon-Carbon Bonds and Identify New Bioconjugation Reagents

Patricia Zhang

Postdoctoral Researcher

University of California Berkeley

Dean Toste Group

Research in the Toste group is primarily aimed toward the development of catalysts, catalytic reactions and methods for organic synthesis. Ultimately, we are interested in using these methods to address problems in the synthesis of complex molecules possessing interesting structural, biological and physical properties. As such, our research program spans the areas of organic synthesis, catalysis, and organometallic chemistry.


ResearchGate Profile

Author Metrics

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