The 5th Annual Big Data in Biology Symposium is the kick-off event for Pop-Up Institute on Individual and Population Variation. The goal of the symposium is to provides a environment where researchers and trainees can interact across traditional disciplinary boundaries. This event is organized by the Center for Computational Biology and Bioinformatics and supported by the Vice President for Research. For information regarding previous Big Data in Biology Symposia, please visit: http://ccbb.utexas.edu/symposium.html